Estrigenix Therapeutics, Inc. Awarded $300,000 Grant from the National Institute of Health

MILWAUKEE (Oct. 17, 2022) – Estrigenix Therapeutics, Inc., a Wisconsin-based, privately held pharmaceutical company leading the way in estrogen biology, has been awarded a $300,000 National Institute of Health (NIH) Small Business Innovation Research (SBIR) Phase I grant. The one-year grant provides funds to support pre-clinical studies on one of Estrigenix’s lead compounds to reduce women’s suffering from the symptoms of menopause and lessen chances for dementia later in a woman’s life.

“This grant from NIH is an important milestone in Estrigenix’s commitment to developing safe and effective treatments that address the negative symptoms experienced by menopausal women without exposing them to increased risks associated with traditional hormone replacement therapy,” explained William Donaldson, Ph.D., chief executive officer (CEO) and co-founder of Estrigenix. “It’s exciting to see our research acknowledged and validated by such a renowned national organization that is committed to our efforts in helping women as they age.”

Studies have shown that as women age, they experience a decrease in estrogen production which can contribute to menopausal symptoms such as hot flashes, sleep disruption, memory dysfunction, anxiety and depression. Many traditional hormone replacement therapies (HRT) address those symptoms, but also come with associated risks for breast cancer and blood clots that can lead to a stroke. Due to these risks, some women avoid taking estrogen all together and suffer through these symptoms.

There are two estrogen receptors, ER alpha and ER beta, in the human body, and estrogen (the main component of HRT) is equally potent in activating these receptors to cause their downstream affects. ER beta is known to control vasomotor symptoms while ER alpha is associated with the proliferations of 80 percent of breast cancer cell lines. Therefore, compounds which are highly selective at activating ER beta (compared to activating ER alpha) have the potential to be safe alternatives to traditional HRT. Estrigenix is working on ER beta agonists to provide menopausal women everywhere with a potentially safer alternative to traditional HRT. The research Estrigenix has conducted, shows that if hot flashes can be reduced, then the risk of dementia in women may also be reduced later in life.

To learn more about Estrigenix and how this new therapy is helping women improve their quality of life, visit


About Estrigenix Therapeutics, Inc.

Estrigenix Therapeutics, Inc. is a Wisconsin-based, privately held pharmaceutical company leading the way in research and progress in estrogen biology. There is a known correlation between the severity of a woman’s hot flashes and her increased risk of developing dementia later in life. Estrigenix was formed in 2018 to develop and commercialize first-in-class therapeutics to treat and prevent hot flashes and dementia in post-menopausal women with fewer side effects than current hormone replacement therapy.

For more information and to learn how Estrigenix is pioneering the way in dementia prevention for post-menopausal women, visit

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