Estrigenix Therapeutics, Inc. presents at Precision Drug Discovery & Preclinical Summit 2023 in Boston

MILWAUKEE (June , 2022) – Estrigenix Therapeutics, Inc., a Wisconsin-based, privately held pharmaceutical company leading the way in estrogen biology, is proud to have been a presenter at the Precision Drug Discovery & Preclinical (PDDP) Summit 2023 in Boston.

William Donaldson, Ph.D., chief executive officer (CEO) of Estrigenix presented an abstract entitled, “Discovery of Selective Estrogen Receptor Beta Agonists as Therapeutics for Hot Flashes and Memory Dysfunction.” The presentation highlighted original Estrigenix research on potentially safe alternatives to traditional hormone therapy (HT).

“The dramatic decline in the production of estrogen during menopause can result in hot flashes, sleep disruption, memory dysfunction, anxiety, and depression in many women,” explained Donaldson. “While traditional HT addresses these symptoms, HT has associated risks for breast cancer and blood clots leading to stroke. For this reason, many OB/GYNs will not prescribe HT for the 19 percent of menopausal women with a history of breast or uterine cancer or stroke.”

Additionally, some women, who are not in these high-risk categories, avoid taking estrogen due to the perceived health risks. Traditional HT is a double-edged sword due to the presence of two estrogen receptors, ER alpha and ER beta. ER beta is known to control vasomotor symptoms while ER alpha is associated with the proliferation of 80 percent of breast cancer cell lines. Thus, highly selective ER beta agonists have the potential to be a safe alternative to traditional HRT.

The Precision Drug Discovery & Preclinical Summit showcases the progress and latest research trends that include new compounds, drug design, synthesis methods, and technologies that advance the science of leaders in the pharma-biotech and academic spaces.

To learn more about Estrigenix and how this new therapy is helping women improve their quality of life, visit


About Estrigenix Therapeutics, Inc.

Estrigenix Therapeutics, Inc. is a Wisconsin-based, privately held pharmaceutical company leading the way in research and progress in estrogen biology. There is a known correlation between the severity of a woman’s hot flashes and her increased risk of developing dementia later in life. Estrigenix was formed in 2018 to develop and commercialize first-in-class therapeutics to treat and prevent hot flashes and dementia in post-menopausal women with fewer side effects than current hormone replacement therapy.

For more information and to learn how Estrigenix is pioneering the way in dementia prevention for post-menopausal women, visit

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