Estrigenix Therapeutics, Inc. presents at American Chemical Society’s Midwest Regional Meeting

MILWAUKEE (Oct. 19, 2022) – Estrigenix Therapeutics, Inc., a Wisconsin-based, privately held pharmaceutical company leading the way in estrogen biology, is presenting atthe Midwest Regional Meeting of the American Chemical Society in Iowa City, Iowa on Wednesday, October 19, 2022.

William Donaldson, Ph.D., chief executive officer (CEO) of Estrigenix is presenting an abstract entitled, “Discovery of Selective Estrogen Receptor Beta agonists as Potential Therapeutics to Treat Hot Flashes and Memory Dysfunction in Menopausal Women.” The presentation focuses on original Estrigenix research regarding potentially safer alternatives to traditional hormone replacement therapy (HRT).

The dramatic decline in the production of estrogen during menopause can result in hot flashes, sleep disruption, memory dysfunction, anxiety, and depression in many women.  While traditional HRT addresses these symptoms, it has associated risks for breast cancer and blood clots leading to stroke. For this reason, many OB/GYNs will not prescribe HRT for the 19 percent of menopausal women with a history of breast or uterine cancer or stroke.

Additionally, some women, who are not in these high-risk categories, avoid taking estrogen due to the perceived health risks.

“Traditional HRT is a double-edged sword due to the presence of two estrogen receptors, ER alpha, and ER beta. ER beta is known to control vasomotor symptoms while ER alpha is associated with the proliferation of 80 percent of breast cancer cell lines. Thus, highly selective ER beta agonists have the potential to be a safe alternative to traditional HRT,” explained Donaldson.

The American Chemical Society is one of the world’s largest scientific societies hosting scientific meetings throughout the country.

To learn more about Estrigenix and how this new therapy is helping women improve their quality of life, visit


About Estrigenix Therapeutics, Inc.

Estrigenix Therapeutics, Inc. is a Wisconsin-based, privately held pharmaceutical company leading the way in research and progress in estrogen biology. There is a known correlation between the severity of a woman’s hot flashes and her increased risk of developing dementia later in life. Estrigenix was formed in 2018 to develop and commercialize first-in-class therapeutics to treat and prevent hot flashes and dementia in post-menopausal women with fewer side effects than current hormone replacement therapy.

For more information and to learn how Estrigenix is pioneering the way in dementia prevention for post-menopausal women, visit

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